DISHEVELLED-1: A NEW PLAYER IN THE DEVELOPMENT OF MYOCARDIAL INFARCTION
Keywords:
acute forms of ischemic heart disease, acute myocardial infarction, dishevelled-1, DVL-1, NF-κB, WNTAbstract
Coronary heart disease remains one of the most common causes of morbidity worldwide and, despite significant progress in treatment, many patients continue to face serious complications after an acute ischemic attack. Given existing data indicating that DVL is a family of proteins that play a key role in WNT signaling, an important signaling cascade involved in the development and homeostasis of many organs and tissues, including the heart, the aim of this study was to determine DVL-1 in serum and evaluate its diagnostic value in patients with acute myocardial infarction.
Material and methods.Fifty patients aged 18 to 59 years diagnosed with acute myocardial infarction were observed. DVL-1 levels were measured using the Sunlong Biotech Co (China) assay system. The control group consisted of 25 healthy individuals, matched for age and gender to those in the study group.
Results. DVL-1 values in patients with acute myocardial infarction were significantly higher than those in healthy individuals and positively correlated with high-specificity troponin in more than 80% of cases. The lowest median DVL-1 values were recorded in posterior wall infarction. Direct correlations were found between DVL-1 and atherogenic profile parameters, β-catenin, and WIF-1, and inverse correlations were found
with NF-κB.
Conclusion. Thus, our data indicate that DVL-1, as a key component of the WNT signaling pathway, is an important new player in the immunopathophysiology of myocardial infarction. Moreover, its role is not limited to the processes of embryogenesis and ontogenesis of the cardiovascular system, but is also realized during ischemia-reperfusion injury in myocardial infarction.
