THE ROLE OF POSITIVE AND NEGATIVE REGULATORS OF HEMAPOYESIS IN THE FORMATION OF ANEMIA OF CHRONIC INFLAMMATION IN GYNECOLOGICAL PATIENTS

Abstract

Aim. To determine the content of negative and positive regulators of hematopoiesis in the blood serum of women with chronic inflammatory diseases of the pelvic organs (PID) and anemia and to evaluate their effect on hematopoiesis.

Material and methods. The study examined the serum levels of cytokines IL-1β, IL-6, IL-10, TNF-a, IFN-γ, as well as erythropoietin, hepcidin, and ferritin (positive and negative regulators of hematopoiesis) in women with chronic pelvic inflammatory diseases complicated by anemia (the main group) and healthy donors (the control group). The main group included 35 patients of average age 37.6±0.7 years. The control group consisted of 20 women (average age 37.1±0.7 years) without pelvic diseases to determine the indicators taken as physiological norm.

Result. The data obtained in the study indicate that all women with chronic inflammatory diseases of the pelvic organs and anemia had significant changes in the cytokine status, the most significant of which are associated with an increase in the level of proinflammatory cytokines. An increase in the amount of erythropoietin in all patients compared with a group of healthy women was also found, combined with hyperferritinemia and a high level of hepcidin in the blood serum.

Conclusion. Chronic inflammatory diseases of the pelvic organs are often accompanied by inflammatory anemia, which in turn is associated with an imbalance in the production of positive and negative regulators of hematopoiesis, primarily cytokines and hepcidin. In this regard, the determination of these indicators can be used as markers of the severity of the anemic syndrome and immune dysfunction in patients with this pathology.