A CLINICAL CASE OF THE USE OF CLOFAZIMINE IN A PATIENT WITH DRUG-RESISTANT PULMONARY TUBERCULOSIS

Abstract

Introduction. The ability of Mycobacterium tuberculosis to develop resistance to both primary and secondary drugs is currently one of the main reasons for the ineffective treatment of various forms of tuberculosis. Phthisiology is constantly developing and refining chemotherapy regimens and regimens to overcome this phenomenon. This article provides a brief literature review on drug-resistant pulmonary tuberculosis and emphasizes the importance of combination chemotherapy in this patient population.

Case description. The main section of the article is devoted to a clinical analysis of a patient with fibrocavernous pulmonary tuberculosis with extensive drug resistance of Mycobacterium tuberculosis. Long-term clinical observation allowed us to evaluate the effectiveness of various chemotherapy regimens. The effectiveness of clofazimine as a reserve anti-tuberculosis drug is emphasized. The duration of chemotherapy was two years and six months, culminating in clinical cure.

Conclusion. Treatment of patients with drug-resistant pulmonary tuberculosis is based on a rationally designed chemotherapy regimen. The ability to use a wide range of drugs with anti-tuberculosis activity allows for effective clinical cure even in cases of widespread disease.