BASAL CELL CARCINOMA AS A COMPONENT OF MALIGNANT POLYNEOPLASIAS REVEALED IN AUTOPSIES AND ITS SIGNIFICANCE IN

Abstract

Aim: according to the literature, the structure of malignant polyneoplasias (MPNP) often contains basal cell carcinoma (BCC), which is the most common malignant skin tumor in elderly patients. Considering the ease of its detection, BCC may be an indicator of the presence of other malignant neoplasias (MN) or a harbinger of the development of metachronous malignancies in the future. In this regard, the aim of the study was to determine the frequency of occurrence of BCC in the structure of MPNP in autopsy material. The choice of autopsy material is due to the fact that when BCC is detected during a biopsy examination, information about the presence or absence of any synchronous MN in these patients is usually absent, and moreover, it is difficult to trace the fate of such patients in relation to possible MN in the future.  Material and methods. the frequency and nosological structure of MPNP was studied on autopsy material in 641 men and 530 women who had different MT.

Results. MPNP were identified in 16 men and 12 women (3,2% and 3,1% of all MN, respectively). BCC were detected in 7 men and 6 women; in men in 6 cases from 7 BCC was a component of MPNP (85,71%), in women – in 5 cases from 6 (83,33%).  In 10 cases out of a total of 11 in which BCC appeared as component of MPNP, the tumor was identified before other MT were diagnosed. Among other MN an increased frequency (8-12%) of the prostate gland carcinoma, laryngeal carcinoma, urinary bladder, mammary glands and ovaries in the structure of MPNP was noted

Conclusion. it has been established that BCC is very often associated with other cancers, forming various variants of MPNP. In view of this, BCC should be considered as a significant marker of the possible presence of other synchronous or increased risk of developing metachronous MN in the future.